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The Environmental Protection Agency (EPA) is the entity responsible for regulating clean water standards in the United States. The EPA was formed to protect human health and the environment, and one of its key functions is to implement the Clean Water Act. This legislation aims to restore and maintain the integrity of the nation's waters by preventing point and nonpoint source pollution, establishing quality standards for surface waters, and overseeing water quality assessments.

The agency sets national water quality standards, enforces compliance, and provides guidance and funding to states and local governments to help manage their water quality programs. This includes regulating wastewater treatment facilities and ensuring that safe drinking water standards are upheld across the country.

In contrast, the other options do not pertain to clean water regulation. The Occupational Safety and Health Administration (OSHA) focuses on workplace safety and health standards, while the Federal Bureau of Investigation (FBI) addresses national security and law enforcement. The Department of Labor concentrates on employment and labor issues, which are separate from water quality management.